Check It!

Check it out!

BCC or not: Sufu keeps it in check

Basal cell carcinoma (BCC), driven by aberrantly activated HEDGEHOG (HH) pathway, is the most common human malignancy. Current FDA-approved targeted therapy uses Vismodegib to inhibit SMO, a membrane component of the HH pathway. Despite initial impressive tumor regression, the positive clinical response is short-lived in some BCC patients as acquired SMO mutations confer secondary resistance[1]...

Holding the inflammatory system in check: NLRs keep it cool

Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repair and resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central to several diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovascular disease. This report aims to review the literature regarding several members of the nu...

Narcissism is Genetic and the Superego Keeps it in Check

In our paper we discuss the existence of narcissism as instinct; a Mendelian trait that can be inherited from either parent. This instinct is an essential component of five different personalities in our model and these personalities can be classified into two groups: Narcissistic and Obsessive. How these personalities manifest in individuals and how the individual interacts with the healthcare...

The Healthy Kids Check - is it evidence-based?

OBJECTIVE To assess whether the components of the Healthy Kids Check (HKC), a preschool screening check recently added to the Australian Government's Enhanced Primary Care Program, are supported by evidence-based guidelines or reviews. DATA SOURCES Guideline and MEDLINE databases were searched for guidelines and systematic reviews published between 2000 and 2008 that were relevant to screenin...